Isolated atrioventricular block of unknown origin in the adult and autoimmunity: diagnostic and therapeutic considerations exemplified by 3 anti-Ro/SSA–associated cases
نویسندگان
چکیده
Pietro Enea Lazzerini, MD, Antonio Brucato, MD, Pier Leopoldo Capecchi, MD, Lucia Baldi, MD, Maria Romana Bacarelli, Tech, Claudia Nucci, MD, Valentina Moscadelli, MD, Gabriella Morozzi, BiolD, Mohamed Boutjdir, PhD, Franco Laghi-Pasini, MD From the Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, Department of Internal Medicine, “Papa Giovanni XXIII” Hospital, Bergamo, Italy, Department of Heart, Thorax and Vessels, University Hospital of Siena, Siena, Italy, Research Department, VA New York Harbor Healthcare System, New York, New York, Departments of Medicine, Cell Biology and Pharmacology, State University of New York at Downstate Medical Center, New York, New York, and Department of Medicine, New York University School of Medicine, New York, New York.
منابع مشابه
Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies.
OBJECTIVE To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. METHODS We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. RESULTS Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had...
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In view of the association of congenital heart block with maternal antibody to cellular antigen Ro (SSA), and one report linking anti-Ro with myocarditis in a patient with myositis an association between anti-Ro antibodies and cardiac disease was sought in adults with systemic lupus erythematosus (SLE). Among 67 patients with SLE, of whom 36 were anti-Ro positive, a significantly higher prevale...
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BACKGROUND Until recently, anti-SSA/Ro antibodies were not considered pathogenic for severe heart disease in adults. Prolongation of the mean QTc interval in electrocardiograms of adult patients with anti-SSA/Ro-positive connective tissue disease has been reported and could contribute to complex arrhythmias in such patients. Furthermore, complete heart block may also be related to these autoant...
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The incidence of CHB is 2 % in cases of maternal anti-Ro/ SSA antibody positivity, 3 % when both anti Ro/SSA and anti-La-SSB are positive. The risk of recurrence is 9 times higher in the subsequent pregnancies [1]. Underlying structural congenital heart disease is associated with more than half of the fetuses found to have CHB and it is then defined ‘‘isolated’’ in the absence of structural hea...
متن کاملFrom antibody insult to fibrosis in neonatal lupus - the heart of the matter
Few diseases exemplify the integration of research from bench to bedside as well as neonatal lupus, often referred to as a model of passively acquired autoimmunity. In essence, this disease encompasses two patients, both the mother and her child. The signature histologic lesion of autoimmune-associated congenital heart block is fibrosis of the conducting tissue, and in some cases the surroundin...
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